Synthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis.

ABSTRACT: Aim: The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g.Methods & materials: Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, ¹H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives. All the derivatives are subjected to in vitro assay against MCF-7 (breast) and anti-bacterial activity.Results: In the anti-bacterial activity compound 3c is moderately active against Escherichia coli (6.0 g/ml), and 4c is extremely active against Lactiplantibacillus plantarum (10.0 g/ml) compared with standard Erythromycin. In cytotoxic activity, the compound

SUBMITTER: Surendrakumar R 

PROVIDER: S-EPMC11622802 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature