Membrane Associated RNA-Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice.

ABSTRACT: Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision-tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. Microdomain calcium (Ca²⁺) transients in astrocytic processes are pivotal for the functional regulation of these processes. However, the understanding of the alterations and regulatory mechanism of microdomain Ca²⁺ transients during stroke remains limited. In the present study, a fast high-resolution, miniaturized two-photon microscopy is used to show that the levels of astrocytic microdomain Ca²⁺ transients are significantly reduced in the peri-infarct area of awake ischemic stroke mice. This

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11633488 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature