Probability of vertical HIV transmission: A systematic review and meta-regression.

ABSTRACT:

Background

Eliminating HIV vertical transmission (VT) is a global priority and monitored by estimating paediatric HIV infections with the Joint United Nations Programme on HIV/AIDS supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART) service delivery models and first-line regimens aimed to reduce VT probabilities. We conducted a systematic review and meta-analysis to estimate VT probabilities by maternal immunologic and treatment status.

Methods

We combined an updated systematic review with previous data in meta-regression models to estimate VT probabilities and determinants. We searched multiple databases for peer-reviewed English-language studies from all regions published between January 2018 and February 2024 with VT da

SUBMITTER: Walters MK 

PROVIDER: S-EPMC11643157 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature