Effect of Chemotherapy on <i>Fusobacterium nucleatum</i> Abundance in Colorectal Cancer Patients: A Study on Relapsing Patients.

ABSTRACT: An intricate relationship exists, and interactions occur between the gut microbiota and colorectal cancer (CRC). Recent studies have indicated that inflammatory reactions stimulated by Fusobacterium nucleatum (Fn) lead to the development of CRC. Radical surgery combined with adjuvant chemotherapy is the primary treatment approach for most CRC patients. This study was designed to evaluate the abundance of Fn as part of the gut microbiota in patients with CRC compared to healthy individuals and to assess the effect of the gut microbiota Fn on patients undergoing adjuvant chemotherapy and those experiencing CRC relapse. There were 201 participants, comprising 50 healthy controls and 151 CRC patients. Stool samples were collected from three CRC groups (postoperative

SUBMITTER: Zuraik AA 

PROVIDER: S-EPMC11645352 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature