2D ¹H sLASER Long-TE and 3D ³¹P Chemical Shift Imaging at 3 T for Monitoring Fasting-Induced Changes in Brain Tumor Tissue.

ABSTRACT:

Background

Emerging evidence suggests that fasting could play a key role in cancer treatment. Its metabolic effects on gliomas require further investigation.

Purpose

To design a multi-voxel ¹H/³¹P MR-spectroscopic imaging (MRSI) protocol for noninvasive metabolic monitoring of cerebral, fasting-induced changes on an individual patient/tumor level, and to assess its technical reliability/reproducibility.

Study type

Prospective.

Population

MRS phantom. Twenty-two patients (mean age = 61, 6 female) with suspected WHO grade II-IV glioma examined before and after 72-hour-fasting prior to biopsy/resection.

Field strength/sequence

3-T, ¹H decoupled 3D ³¹P MRSI, 2D ¹H sLASER MRSI at an echo time of 144 msec,

SUBMITTER: Alcicek S 

PROVIDER: S-EPMC11645487 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature