The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach.

ABSTRACT:

Background

Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.

Method

We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. Mo

SUBMITTER: Li Y 

PROVIDER: S-EPMC11645663 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature