BATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease.

ABSTRACT:

Background

Coronary heart disease (CHD) represents a significant global health concern, arising from an intricate interplay between genetic predisposition and environmental influences, with a pivotal involvement of oxidized low-density lipoprotein (ox-LDL) in the pathophysiology of it. We aimed to elucidate the synergistic dynamics of B cell activating transcription factor (BATF) and Sirtuin 1 (SIRT1) in cell injury caused by ox-LDL, reveal potential therapeutic strategies for CHD.

Methods

The GSE42148 dataset was used to analyze Differentially expressed genes (DEGs) to construct a gene co-expression network. Then bioinformatics analysis was performed on key modules to select the BATF gene. In vitro experiments were conducted to investigate the protective impact of BATF agai

SUBMITTER: Tian B 

PROVIDER: S-EPMC11649077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature