The geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.

ABSTRACT:

Background

Drug use Disorder (DUD), the risk for which is substantially influenced by both genetic and social factors, is geographically concentrated in high-risk regions. An important step toward understanding this pattern is to examine geographical distributions of the genetic liability to DUD and a key demographic risk factor - social deprivation.

Methods

We calculated the mean family genetic risk score (FGRS) for DUD ((FGRS_DUD) and social deprivation for each of the 5983 areas Demographic Statistical Areas (DeSO) for all of Sweden and used geospatial techniques to analyze and map these factors.

Results

Using 2018 data, substantial spatial heterogeneity was seen in the distribution of the genetic risk for DUD in Sweden as a whole and in its three major u

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC11650187 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature