The expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer.

ABSTRACT:

Background

Accumulating evidence has demonstrated that the long non-coding RNA (lncRNA) lymphocytic leukaemia deletion gene 1 (DLEU1) is abnormally overexpressed in many cancer types, including cervical cancer (CC). However, the potential clinical significance of DLEU1 in serum exosomes of patients with CC remains unclear.

Methods

The expression of serum exosomal DLEU1 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was plotted to evaluate the clinical diagnostic efficacy of DLEU1. The Kaplan-Meier survival curve and Cox proportional hazards model were used to assess the effect of DLEU1 on postoperative recurrence, metastasis and prognosis among patients with CC.

Results

Our research showed th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11654034 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature