Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.

ABSTRACT: Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the

SUBMITTER: Lan H 

PROVIDER: S-EPMC11656764 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature