Data mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders.

ABSTRACT:

Background

H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.

Aims

We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.

Methods

Disproportionality analysis was used to identify the suspected drug neurological adverse events associated with H1-antihistamines of interest via the Food and Drug Administration Adverse Event Reporting Sys

SUBMITTER: Hu W 

PROVIDER: S-EPMC11656970 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature