The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis.

ABSTRACT:

Background

The pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high-IgE levels are a poor prognostic factor in gastrointestinal allergies.

Methods

This study investigated how high-IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.

Results

Ovalbumin-sensitized and egg-white diet-fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulatio

SUBMITTER: Zubeldia-Varela E 

PROVIDER: S-EPMC11657046 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature