Altered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease.

ABSTRACT:

Background

Adults with congenital heart disease (ACHD) display changes in adaptive immunity related to early open-heart surgery and subsequent incidental thymectomy. In acquired heart failure (HF) systemic inflammation, innate and adaptive immune cells play an important role. However, cellular immune alterations of monocyte, T lymphocyte and natural killer (NK) cell subsets have not been related to HF in ACHD.

Methods and results

This cross-sectional study included 209 ACHD outpatients (mean age: 35.3 ± 11.0 years; NYHA class I/II/III-IV 64.1%/21.5%/14.4%; 59.8% male) and 21 healthy controls (29.8 ± 12.6 years; 47.6% male). Patients with clinical signs of infection, inflammatory diseases or malignancies were excluded. Flow cytometry of fresh whole blood revealed significantl

SUBMITTER: Wienecke LM 

PROVIDER: S-EPMC11657347 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature