An integrative data-driven model simulating C. elegans brain, body and environment interactions.

ABSTRACT: The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we inves

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11659166 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature