Common diagnostic biomarkers and molecular mechanisms of Helicobacter pylori infection and inflammatory bowel disease.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of H. pylori in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between H. pylori and IBD.

Methods

The following matrix data were downloaded from the GEO database: H. pylori-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein-protein interaction (PPI) network of DEGs was constructed via the STRING database. Cyt

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11659760 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature