New quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.

ABSTRACT: A novel molecular design based on a quinazolinone scaffold was developed via the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like Bacillus subtilis, Staphylococcus aureus (Gram-positive), Pseudomonas aeruginosa, Klebsiella pneumonia, Sallmonella Typhimurium (Gram-negative), in addition to Candida albicans (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs. Notably,

SUBMITTER: Kassem AF 

PROVIDER: S-EPMC11726445 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature