Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis.

ABSTRACT:

Objectives

This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.

Method

We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.

Results

Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290-1.040, P =

SUBMITTER: Lee YH 

PROVIDER: S-EPMC11729962 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature