Isolation of phages infecting the zoonotic pathogen <i>Streptococcus suis</i> reveals novel structural and genomic characteristics.

ABSTRACT: Bacteriophage research has experienced a renaissance in recent years, owing to their therapeutic potential and versatility in biotechnology, particularly in combating antibiotic resistant-bacteria along the farm-to-fork continuum. However, certain pathogens remain underexplored as targets for phage therapy, including the zoonotic pathogen Streptococcus suis which causes infections in pigs and humans. Despite global efforts, the genome of only one infective S. suis phage has been described. Here, we report the isolation of two phages that infect S. suis: Bonnie and Clyde. The phages infect 58% of 100 S. suis strains tested, including representatives of seven different serotypes and thirteen known sequence types from diverse geographical origins. Clyde suppressed

SUBMITTER: Osei EK 

PROVIDER: S-EPMC11741397 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature