Investigating T Cell Immune Dynamics and IL-6's Duality in a Microfluidic Lung Tumor Model.

ABSTRACT: Interleukin 6 (IL-6), produced by immune cells, is crucial in promoting T cell trafficking to infection and inflammation sites, influencing various physiological and pathological processes. Concentrations of IL-6 and other cytokines and chemokines can influence T cell differentiation and activation. Understanding the dual faces of IL-6 within the tumor microenvironment is crucial to understanding its role. A flow-based microsystem was designed to investigate CD4⁺ T cell activation in response to different IL-6 gradients in an under-control 3D culture. The study found that cancer cells' response to varying IL-6 concentrations was dynamic and dose-sensitive, with immune cell migration rates showing sensitivity to the IL-6 gradient. A549 cell expansion increases gradually and time-

SUBMITTER: Sardarabadi P 

PROVIDER: S-EPMC11758792 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature