Post-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis.

ABSTRACT:

Background

Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by complications such as strictures, fistulas, and neoplasia. Despite medical advancements, a significant number of patients with Crohn's disease require surgery, and many experience post-operative complications and recurrence. Previous studies have analyzed gene expression to study recurrence and post-operative complications independently. This study aims to identify overlapping differentially expressed genes and pathways for recurrence and post-operative complications.

Methods

A dataset including 45 patients with Crohn's disease, including gene expression from ileum and colon tissue, endoscopic recurrence, and intra-abdominal septic complications was anal

SUBMITTER: Chen KA 

PROVIDER: S-EPMC11761463 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature