Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.

ABSTRACT:

Background

Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.

Methods

Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in Caenorhabditis elegans, with a focus on mitophagy pathways.

Results

GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expre

SUBMITTER: Kim M 

PROVIDER: S-EPMC11764779 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature