Ocular inoculation of toad venom: toxic cataract and proteomic profiling.

ABSTRACT:

Purpose

To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.

Methods

A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery. Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.

Results

A multitude of differentially expressed proteins (DEPs) were identified in the patie

SUBMITTER: Lyu D 

PROVIDER: S-EPMC11772289 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature