Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.

ABSTRACT:

Introduction

Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of Rheum L. of Polygonaceae Juss. has many pharmacological activities such as anti-inflammatory, antioxidant, antiproliferative, and antithrombotic properties. However, its effects on HF remain unclear.

Methods

Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl₄)-induced hepatic fibrosis

SUBMITTER: Yang M 

PROVIDER: S-EPMC11772292 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature