α-Pyrrolidinooctanophenone facilitates activation of human microglial cells via ROS/STAT3-dependent pathway.

ABSTRACT:

Purpose

Pyrrolidinophenone derivatives (PPs) are amphetamine-like designer drugs containing a pyrrolidine ring, and their adverse effects resemble those of methamphetamine (METH). Microglial activation has been recently suggested as a key event in eliciting the adverse effects against dysfunction of the central nervous system. The aim of this study is to clarify the mechanisms of microglial activation induced by PPs.

Methods

We employed the human microglial cell line HMC3 to assess microglial activation induced by PPs and evaluated the capacities for proliferation and interleukin-6 (IL-6) production that are characteristic features of the activation events.

Results

The WST-1 assay indicated that viability of HMC3 cells was increased by treatment with sublethal concent

SUBMITTER: Sakai Y 

PROVIDER: S-EPMC11782452 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature