Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.

ABSTRACT: Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline). Greater decline in D2/3 dopamine receptor availability in working memory-relevant regions (caudate, middle frontal cortex, hippocampus) was related to greater decline in working memory

SUBMITTER: Papenberg G 

PROVIDER: S-EPMC11795306 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature