Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have revealed relationships between circulating vitamin D concentrations and the risk of different types of cancer, although the potential causal relationship remains controversial. This study aims to investigate the presence of a causal relationship between circulating vitamin D concentrations and the risk of different types of cancer.

Methods

Summary statistics from corresponding genome-wide association studies (GWASs) were used to investigate the causal relationship between circulating vitamin D concentrations and the risk of 14 cancers. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighting (IVW) as the primary method was performed. Additionally, the results were verified using four other methods, including MR

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11796945 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature