Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial.

ABSTRACT:

Objectives

Postoperative nausea and vomiting (PONV) is common after video-assisted thoracic surgery, which may be associated with the use of intraoperative opioids. We tested the hypothesis that balanced opioid-free anesthesia (OFA) might reduce the incidence of PONV after video-assisted thoracic surgery.

Methods

One hundred and sixty-eight adults undergoing video-assisted thoracic assisted surgery were randomly assigned to receive balanced opioid-free anesthesia or balanced opioid-based anesthesia (OBA). The primary outcome was the incidence of PONV, which was assessed with the Myles's simplified PONV impact scale during the initial 24 h after surgery.

Results

Compared with OBA group, the overall incidence of PONV in OFA group was significant reduced (14.6% vs. 30.1%

SUBMITTER: Yan X 

PROVIDER: S-EPMC11806895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature