CPEB3 can regulate seizure susceptibility by inhibiting the transcriptional activity of STAT3 on NMDARs expression.

ABSTRACT:

Background

The pathogenesis of epilepsy is complex, and current antiepileptic drugs do not effectively control the seizures. Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates neuronal excitability, but its mechanism of action in epilepsy is not clear. In this paper, we investigated the effect of CPEB3 on seizures and elucidated its underlying molecular mechanism.

Methods

Bioinformatics-based search for genes closely associated with epilepsy. Changes in expression and cellular localization of CPEB3 in epilepsy were verified by western blotting (WB) and Immunofluorescence staining. Subsequently, The adeno-associated virus was employed to overexpress or knockdown in mice. Behavioral experiments verified the effect of CPEB3 on epileptic phenotype, and the m

SUBMITTER: You Z 

PROVIDER: S-EPMC11852879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature