Intraoperative redosing of antibiotics for prevention of surgical site infections: A systematic review and meta-analysis.

ABSTRACT:

Background

Appropriate antibiotic prophylaxis is essential for preventing surgical site infections (SSI); however, the clinical benefit of intraoperative redosing remains unclear and controversial owing to insufficient reliable evidence. Therefore, we performed a systematic review and meta-analysis to assess the effectiveness of prophylactic antibiotic redosing in lengthy surgical procedures.

Methods

We systematically searched the PubMed, Cochrane Library, Web of Science, and Ichushi-Web databases for articles published until 31 December, 2023. We compared the incidence of SSI between patients receiving and not receiving intraoperative redosing of antibiotics in surgeries lasting ≥3 h. Subgroup analyses were conducted across study characteristics. Odds ratios (ORs) and 95% c

SUBMITTER: Hanai Y 

PROVIDER: S-EPMC11877348 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature