Population-Scale Studies of Protein S Abnormalities and Thrombosis.

ABSTRACT:

Importance

Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.

Objective

To evaluate the risk associated with protein S deficiency across multiple thrombosis phenotypes.

Design, setting, and participants

Cross-sectional study using longitudinal population cohorts derived from the UK Biobank (n = 426 436) and the US National Institutes of Health All of Us (n = 204 006) biorepositories. UK Biobank participants were enrolled in 2006-2010 (last follow-up, May 19, 2020) and underwent

SUBMITTER: Chaudhry SA 

PROVIDER: S-EPMC11877412 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature