Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.

ABSTRACT:

Background

Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.

Purpose

To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.

Methods

We recruited 250 participants, including healthy individuals and patients diagnosed with SZ. Serum metabolomics and proteomics analyses were performed to screen common pathways. Along with the biological significance of common pathways, a common pathway-symptom correlation diagram was constructed to elucidate the pathological mechanism underlying the occurrence and development of SZ. The enrichment sco

SUBMITTER: Wang W 

PROVIDER: S-EPMC11890557 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature