Manganese-Loaded pH-Responsive DNA Hydrogels Enable Tg-Guided Thyroid Tumor Targeted Magnetic Resonance Imaging.

ABSTRACT: The diagnosis of metastatic and recurrent occult thyroid cancer presents a significant challenge. This study introduces a DNA-Mn hydrogel (M-TDH) that specifically targets thyroglobulin (Tg). This nanogel is loaded with paramagnetic Mn²⁺ for facilitating magnetic resonance (MR) imaging. As a cofactor of DNA polymerase, Mn²⁺ promotes the extension of long-strand DNA and forms Mn₂PPi nuclei with PPi^4- in the system. The synthesis of M-TDH is achieved through Mn₂PPi nucleation and growth with long-strand DNA acting as the structural framework. The X-scaffold functions as a junction point, thereby enhancing structural stability. The Tg aptamer sequence is incorporated into M-TDH, ensuring specific targeting of thyroid cancer cells. Further

SUBMITTER: Hu Q 

PROVIDER: S-EPMC11891823 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature