Ruthenium-Catalyzed Transfer Hydrogenation of Alkynes: Access to Alkanes and (<i>E</i>)- or (<i>Z</i>)-Alkenes in Tandem with Pd/Cu Sonogashira Cross-Coupling.

ABSTRACT: A complete reduction of alkynes using a combination of [RuCl₂(p-cymene)]₂, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52-99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38-99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed cis-trans alkene isomerization step.

SUBMITTER: Jankovic D 

PROVIDER: S-EPMC11894645 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature