Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.

ABSTRACT: Understanding the specific role and underlying mechanisms of mitophagy may provide therapeutic benefit to patients with nasopharyngeal carcinoma (NPC). Forkhead box D1 (FOXD1), is overexpressed in NPC. However, its roles in NPC progression and therapy resistance remain largely unknown. NPC tissues displayed increased FOXD1 expression compared to paired non-tumor tissues, which correlated with worse overall survival (OS). Upregulation of FOXD1 promoted NPC cell proliferation, colony formation, migration, invasion, and impaired sensitivity to GEM by enhancing mitophagy levels. Mechanistically, FOXD1 promoted mitophagy in NPC cells by transcriptionally initiating BNIP3 expression. This enhanced mitophagy, in turn, promoted proliferation, invasion, and migration and

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11900802 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature