Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority randomized controlled trial.

ABSTRACT:

Aim(s)

To investigate the impact of the absence of specific advice for oral fluid intake, compared to supplementation water intake on the occurrence of post-dural puncture headache.

Design

A prospective, open-label, non-inferiority, multicenter trial including hospitalized patients requiring a diagnostic lumbar puncture in seven hospitals in France.

Methods

Patients were randomly allocated (1:1) either to receive no specific advice on oral fluid intake (FREE-FLUID), or to be encouraged to drink 2 liters of water (CONTROL) within the 2 hours after lumbar puncture. The primary outcome was the post-dural puncture headache rate within the 5 days after lumbar puncture, with a non-inferiority margin of 10%. The secondary outcome was the time-to-post-dural puncture headache

SUBMITTER: Cartron E 

PROVIDER: S-EPMC11903041 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature