Investigating the Mechanism of IFN-γ-Inducible Lysosomal Thiol Reductase-Mediated Inhibition of Breast Cancer Cell Proliferation.

ABSTRACT:

Background

Breast cancer has become a severe threat to human health, making it imperative to identify effective drugs and therapeutic targets.

Methods

Various molecular biology experiments, such as western blot analysis, cytologic effect, co-immunoprecipitation, and immunofluorescence assays, as well as a nude mouse xenograft tumor model, were used to comprehensively analyze the impact of gamma-interferon-inducible lysosomal thiol reductase (GILT) on the malignant phenotype of breast cancer cells. This work was performed to examine GILT expression levels and explore the potential mechanism in breast cancer.

Results

GILT protein expression levels were significantly lower in breast cancer cells than in normal breast epithelial cells. Overexpressing GILT inhibited breast

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11909800 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature