Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy.

ABSTRACT:

Objective

Graves' orbitopathy (GO) is characterized by increased production of proinflammatory cytokines and hyaluronic acid by fibroblasts and their differentiation into adipocytes in response to immunologic stimuli. The suppressor of cytokine signaling-3 (SOCS3) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic pathogenesis of GO.

Methods

Transcriptome profiling of orbital tissues obtained from five patients with GO who underwent orbital decompression surgery and four healthy subjects was performed using RNA-sequencing. Among the top-ranked differentially expressed genes, we identified 24 hub genes and found SOCS3 to be th

SUBMITTER: Kim W 

PROVIDER: S-EPMC11913680 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature