Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure.

ABSTRACT:

Background

Ionizing radiation (IR) exposure poses a significant health risk due to its widespread use in medical diagnostics and therapeutic applications, necessitating rapid and effective biomarkers for assessment.

Objective

The aim of this study is to identify the serum proteomic signature of IR exposure in patients undergoing radiotherapy (RT).

Methods

Blood samples were obtained from eighteen patients with head and neck cancer (HNC) and five patients with rectal cancer before and immediately after they underwent curative intensity-modulated radiotherapy (IMRT). The comprehensive serum proteome was analyzed in individual samples using nanoHPLC-MS/MS.

Results

Forty radiation-modulated proteins (RMPs), 24 upregulated and 16 downregulated, with a fold change ≥1

SUBMITTER: Zebene ED 

PROVIDER: S-EPMC11940482 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature