The influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review.

ABSTRACT:

Introduction

Several measures of cardiovascular health have been investigated as potential risk factors for development of cognitive decline in mid-to later-life, among them, circulating cholesterol. However, the efficacy of midlife interventions aimed at reducing blood cholesterol to mitigate the risk of cognitive decline is uncertain, with conflicting evidence reported from a range of longitudinal and cross-sectional studies. This review systematically investigates the connection between cholesterol measures in midlife and their impact on cognitive function in both mid- and later-life.

Methods

Electronic databases were explored from their inception until December 2023. Studies that evaluated the relationship between cholesterol and its sub-components in midlife (40-65 year

SUBMITTER: Joyce OC 

PROVIDER: S-EPMC11962029 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature