The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.

ABSTRACT:

Significance

We describe the identification of a previously unrecognized ubiquitin ligase-substrate (FBXO45-GEF-H1) regulatory axis that plays an important role in germinal center formation and pathogenesis of common BCLs. These studies reveal novel insights linking dysregulated ubiquitin-mediated control to exploitable vulnerabilities and novel therapeutic strategies for these cancers.

SUBMITTER: Sahasrabuddhe AA 

PROVIDER: S-EPMC11962402 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature