Could optical coherence tomography detect monosodium urate crystal deposition at artery walls? An exploratory, phantom-based study.

ABSTRACT:

Objective

Some reports suggest monosodium urate (MSU) crystals may deposit in artery walls. This exploratory study evaluated the capacity of optical coherence tomography (OCT) to detect MSU crystals in vessel phantoms.

Methods

We used 3D-printed blood vessel phantoms made of photosensitive acrylic resins, with varying compliances. 0.1cc volume injections of centrifugated human synovial fluids containing MSU crystals, calcium pyrophosphate crystals or 0.9% saline were performed in four predefined locations in the phantoms. OCT was subsequently performed in a blinded manner by two cardiologists, experts in the technique. Two exploratory definitions for MSU crystal deposits were used, depicting a lesion with high attenuation (#1) or also with a linear morphology (#2). Diagnosti

SUBMITTER: Sanchez-Pujol J 

PROVIDER: S-EPMC11967950 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature