Cytotoxicity-guided isolation of elatostemanosides I-VI from <i>Elatostema tenuicaudatum</i> W. T. Wang and their cytotoxic activities.

ABSTRACT: Elatostema tenuicaudatum W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I-VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC₅₀ values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC₅₀ value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the

SUBMITTER: Huynh QT 

PROVIDER: S-EPMC11970508 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature