Impact of Severe COVID-19 on Accelerating Dementia Onset: Clinical and Epidemiological Insights.

ABSTRACT:

Importance

Severe COVID-19 infection has been associated with neurological complications, but its role in accelerating cognitive decline remains unclear.

Objective

To determine whether individuals hospitalized for severe COVID-19 exhibit a higher incidence of new onset cognitive impairment compared to those hospitalized for other conditions.

Design

A retrospective study emulating a target trial using Mass General Brigham electronic health records (March 2020-August 2024). The causal effect of COVID-19 hospitalization was estimated via cumulative incidence functions accounting for the competing risk of death.

Setting

Multicenter hospital-based study across the Mass General Brigham healthcare system.

Participants

A total of 221613 hospitalized patients met

SUBMITTER: Mukhija S 

PROVIDER: S-EPMC11974976 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature