Effects of cerebellar transcranial direct current stimulation on reversal learning performance during threat of shock.

ABSTRACT: According to the cerebellar lateralization hypothesis of motivational direction, relative left-to-right dominant posterior cerebellar activity is associated with avoidance motivation and anxiety, whereas relative right-to-left dominant posterior cerebellar activity is associated with approach motivation and anger. The present study tested this hypothesis in avoidance-related behavior during rule learning combined with threat of shock. In a randomized double-blind sham-controlled between-subjects design, ninety healthy right-handed adult volunteers received either active (n = 45) or sham (n = 45) cerebellar left anodal-right cathodal transcranial direct current stimulation (tDCS) to the posterior cerebellum. During tDCS participants performed a gambling task with two changing

SUBMITTER: Kruithof ES 

PROVIDER: S-EPMC11979461 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature