Brain metastasis of pleuropulmonary blastoma: case reports.

ABSTRACT:

Background

Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant tumor of the lung or pleura, primarily affecting children and closely associated with DICER1 gene mutations. Patients with type II and III PPB are prone to distant metastasis, with the central nervous system (CNS) being the most common site of metastasis, leading to a poor prognosis.

Case description

This article provides a detailed account of the clinical manifestations, diagnostic processes, treatment plans, and follow-up outcomes of three children diagnosed with PPB accompanied by brain metastasis. Through the collaborative diagnosis and treatment by a multidisciplinary team, all three patients are currently in remission. As part of the diagnostic and treatment process, genetic test

SUBMITTER: He S 

PROVIDER: S-EPMC11983002 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature