<i>Faecalibacterium prausnitzii</i> Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS-Induced Colitis Mice Model.

ABSTRACT: Background: Reduction of Faecalibacterium prausnitzii abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. Aim: This study aimed to establish a F. prausnitzii-colonized mouse model and investigate that the presence of F. prausnitzii in the gut can ameliorate the severity of dextran sulfate sodium (DSS)-induced colitis. Methods: A F. prausnitzii (ATCC 27768) strain was maintained on the PS-BHI agar plates and manipulated in a strictly anaerobic chamber. A F. prausnitzii-colonized C57BL/6 mice model was tested by a rectal enema with 1 × 10⁹ bacteria/day for 3 days. The 5% DSS was added to drinking water for 3 days to induce colitis and diarrhea in experimental mice. The c

SUBMITTER: Liu MC 

PROVIDER: S-EPMC11986197 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature