Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France).

ABSTRACT:

Background

The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever.

Aim

We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed to animals and/or tick bites due to occupational activities.

Methods

This cross-sectional study involved two groups: anonymized RS from medical biology laboratories and sera from high-risk individuals (slaughterhouse workers, veterinary professionals, animal farmers, and rangers) collected across Corsica during 2022-2023. Antibodies targeting the CCHFV viral nucleoprotein were detected using a double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody test

SUBMITTER: Kiwan P 

PROVIDER: S-EPMC11995033 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature