Hematochemical hallmarks as markers of pulmonary TB severity: A multicenter cross-sectional study.

ABSTRACT:

Background

Identifying accessible and reliable biomarkers for tuberculosis (TB) severity is crucial for improving patient management. This study evaluates hematological findings as potential indicators of TB severity in a large multicenter Italian cohort.

Methods

This retrospective, multicenter, cross-sectional study analyzed hematological parameters (hemoglobin, white blood cells, inflammatory indices, hepatorenal function, albuminuria) in 577 TB patients from 10 Italian centers (2018-2023). Severe TB was defined by at least two criteria: TIMIKA score > 60, sputum conversion time > 21 days, or need for oxygen supplementation. Statistical analyses included receiver operating characteristic curve (AUC) evaluation, calibration curves, and clinical utility.

Results

Of th

SUBMITTER: Di Gennaro F 

PROVIDER: S-EPMC11999573 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature