Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.

ABSTRACT:

Introduction

Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III interferon-regulated genes (Interferome) remains largely uncharacterized in uveitis.

Methods

In this study, we conducted an integrative systems biology analysis of blood transcriptome data from 169 non-infectious uveitis patients (56 isolated uveitis, 113 systemic disease-associated uveitis) and 82 healthy controls.

Results

Modular co-expression analysis identified distinct cytokine signaling networks, emphasizing interleukin and interferon pathways. A meta-analysis revealed

SUBMITTER: Munhoz DD 

PROVIDER: S-EPMC12014655 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature