Targeted metabolomics unravels the mechanism by phenylpropanoid-rich of the peel of <i>Zea mays</i> L. ameliorates metabolic disorders in diabetic mice through gut microbiota modulation.

ABSTRACT:

Background

Diabetes is one common clinical symptoms of metabolic disorders. The peel of Zea mays L. is a folk remedy for diabetes that has not been thoroughly studied. The effects and mechanisms on diabetes complicated glucose and lipid metabolism disorders are still unknown now.

Purpose

The research is intended to elucidate the constituent of phenylpropanoid enriched of Zea mays L. (YMP), and investigate the treatment and mechanism on amending glucose and lipid metabolism disorders.

Methods

The constituents of YMP were systematacially identified by HPLC-Q-TOF-MS/MS and NMR. To assess the effects of varying YMP doses, diabetic mice induced by streptozotocin and a high-fat diet were divided into groups. Targeted serum metabolomics investigations were cond

SUBMITTER: Cheng X 

PROVIDER: S-EPMC12014729 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature